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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are often characterized by a focus on the practical aspects of the study design, including recruitment and consent in adherence, as well as the use of standard equipment.
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A pragmatic study that involves different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is vital for pragmatic trials to be reliable and reduce bias in results is also essential. However too much heterogeneity could result in problems with the design of the trial.
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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are typically commissioned by policymakers and practitioners to help guide their decisions. They can also be used to determine the causal relationship between an intervention and its effects. However, 프라그마틱 카지노 should not be used to substitute for explanation trials.
The pragmatism idea is controversial, and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the clinical or physiological hypothesis, and pragmatic trials, which inform the practice and policy decisions. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool sought to define the elements of a pragmatic trial which includes recruitment, design and delivery of the intervention, and monitoring.
There is an encouraging increase in the number pragmatic trials that have been published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This is an indication that the health science community is becoming increasingly sensitized to the subject of pragmatics. However, it is important to remember that the majority of these trials were conducted in primary care settings.